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On behalf of the congress administrative and scientific committee, we warmly welcome you to the 42nd Congress of the Egyptian Society of Nephrology and Transplantation (ESNT) that will be held between 13-16 February 2023 in Cairo-Egypt. This year, the event is endorsed by the African Association of Nephrology (AFRAN) and The Arab Society of Nephrology and Transplantation (ASNRT). Thanks to the cooperation of the International Society of Nephrology (ISN) and Mayo Clinic. The theme of this congress is “Bridging the gaps & facing challenges in nephrology practice”. Major challenges need to be addressed to accomplish our goals of optimizing the standard of care for all renal patients. We are gathered here today to exchange knowledge and promote interaction toward the optimization of nephrology practice. We are privileged to have, besides our eminent Egyptian experts, guest speakers from the Arab world, Africa, Europe, and the USA who will enrich our scientific program. We promise you that this year’s program will meet your expectations and you will enjoy your stay in Egypt, the cradle of civilization.